This became particularly evident 10 years ago, when two missense mutations in CaM were found to be associated with heart failure and sudden cardiac death due to Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT) and long QT syndrome (LQTS) (Nyegaard et al., 2012). This evidence concerns the gene CALM1 and catecholaminergic polymorphic ventricular tachycardia.