We conducted a comprehensive biophysical investigation of the structural, kinetic, and thermodynamic properties underlying the association between peptides comprising the analogous RyR1/RyR2 regions and three CaM variants, namely the wild type protein and the N97I and Q135P variants (Figure 1A), which are associated with LQTS and LQTS/CPVT, respectively (Jensen et al., 2018). The gene discussed is RYR2; the disease is catecholaminergic polymorphic ventricular tachycardia.