TSPAN4 expression was highly expressed in atherosclerosis and can also be prognostic biomarkers in patients with ACC, GBM, LGG, LUSC, MESO, PCPG, PRAD, THYM, UVM, THCA, GBMLGG or LUADLUSC, while TSPAN4 expression can be diagnostic biomarkers in patients with LUSC, UCS, THYM, KIRC, PAAD, OV, DLBC, CESC and UCEC (AUC > .9) as well as LUAD, LIHC, PRAD, KICH, ESCA, BLCA, GBM, KIRP, BRCA, READ and COADREAD (AUC > .8). This evidence concerns the gene TSPAN4 and adrenal cortex carcinoma.