NLRP3 and isolated hemihyperplasia: Thus, the NLRP3 inflammasome is strongly induced in EC upon pro-inflammatory exposure, and inhibition of NLRP3 inflammasome improves EC recovery and limits IH in various models (Xia et al., 2014; Koka et al., 2017; Wei et al., 2019; Li et al., 2022).