Additional studies in the context of atherosclerosis reported that 30%–70% of plaque cells originate from VSMC (Shankman et al., 2015; Chappell et al., 2016), while up to 80% of VSMC-derived cells in the plaques do not express the VMSC markers Acta2 (Gomez et al., 2013; Shankman et al., 2015). The gene discussed is ACTA2; the disease is atherosclerosis.