APOE and obesity due to melanocortin 4 receptor deficiency: Notably, valve dysfunction in the Western diet-induced obesity model was only observed in mesenteric and not in popliteal collecting lymphatics (Castorena-Gonzalez, 2022), in contrast to the hyperpermeability of mesenteric collectors and both valve and contractile dysfunction in popliteal collectors of ApoE−/− mice fed a HFD.