APOE and cardiovascular disorder: This is a well-established mouse model of cardiovascular disease (Ilyas et al., 2022), in which a diet rich in fat and cholesterol on an ApoE deficient background accelerates the development of hypercholesteremia, atherosclerotic plaque development (Zhao et al., 2020) and inflammation of the skin and other tissues (Feingold et al., 1995; van Ree et al., 1995).