In atherosclerosis, NLRP3 is activated by cholesterols crystals (Duewell et al., 2010; Rajamäki et al., 2010) and oxidized LDL (Jiang et al., 2012; Sheedy et al., 2013; Liu et al., 2014; Oury, 2014). The gene discussed is NLRP3; the disease is atherosclerosis.