Additionally, while we found no response in whole-body measures of insulin resistance in our main IDEAL Study cohort [reported elsewhere (Skelly et al., 2021)], it is important to note that serum sclerostin levels appear to be elevated in individuals with prediabetes and correlate with insulin resistance in skeletal muscle, liver, and adipose tissue (Daniele et al., 2015). This evidence concerns the gene SOST and prediabetes syndrome.