Hou et al. found that LINC00460/DHX9/IGF2BP2 complex may regulate the expression of high mobility group AT-hook 1 (HMGA1) by recognizing the m6A modification site of HMGA1, thereby enhancing its mRNA stability and promoting the metastasis of colorectal cancer (Hou et al., 2021). The gene discussed is IGF2BP2; the disease is colorectal cancer.