Hou et al. found that LINC00460/DHX9/IGF2BP2 complex may regulate the expression of high mobility group AT-hook 1 (HMGA1) by recognizing the m6A modification site of HMGA1, thereby enhancing its mRNA stability and promoting the metastasis of colorectal cancer (Hou et al., 2021). This evidence concerns the gene HMGA1 and colorectal cancer.