SEC62 and metastatic malignant neoplasm in the lymph nodes: SEC62 overexpression in tumor tissue compared with tumor-free tissue has been observed for lung, prostate, and cervical cancers at the protein and mRNA levels, and high SEC62 expression has been found to correlate with lymph node metastasis and poorer overall prognosis (Linxweiler et al., 2012, 2013, 2016; Wemmert et al., 2016).