Chen et al. observed the significant upregulation of miR-146a expression in GC cells from POF patients, and miR-146a induced GC apoptosis by targeting IRAK1 (interleukin-1 receptor-associated kinase) and TRAF6 (tumor necrosis factor receptor-associated factor 6) (Chen et al., 2015). The gene discussed is IRAK1; the disease is premature menopause.