39 reported that hypercholesterolemia is caused by elevated cholesterol absorption in the intestine due to insulin deficiency. Studies also have shown that high cholesterol and triglyceride levels can be reduced by insulin treatment40. ,41 Therefore, the improvement of insulin levels from the treatment of both gallic acid and andrographolide in diabetic rats is correlated with the reduction of total cholesterol and triglyceride levels in the current study. The gene discussed is INS; the disease is Hypercholesterolemia.