Some immunodeficiency diseases, such as adenosine deaminase (ADA) deficiency (Scott et al., 2017), DiGeorge syndrome (Kobrynski & Sullivan, 2007), and STAT5b deficiency (Bernasconi et al., 2006) manifested as the abnormal development of cartilage. This evidence concerns the gene ADA and hyperinsulinemic hypoglycemia, familial, 4.