B cell receptor signaling pathway, epithelial cell signaling in helicobacter pylori infection, legionellosis, leishmaniasis and rheumatoid arthritis were significantly enriched in the high MCEMP1 subgroup (Figure 8E), whereas taste transduction and olfactory transduction were significantly enriched in the low MCEMP1 subgroup (Supplementary Figure 2E). The gene discussed is MCEMP1; the disease is rheumatoid arthritis.