ACSL1 and rheumatoid arthritis: Additionally, immune-related pathways such as B cell receptor signaling pathway, graft-vs.-host disease, legionellosis, leishmaniasis, and rheumatoid arthritis were significantly enriched in the high ACSL1 subgroup (Figure 8A), while metabolism-related pathways such as butanoate metabolism, linoleic acid metabolism, and taurine and hypotaurine metabolism were significantly enriched in the low ACSL1 subgroup (Supplementary Figure 2A).