Epithelial cell signaling in helicobacter pylori infection, graft-vs.-host disease, legionellosis, leishmaniasis and pertussis were significantly enriched in the high IRAK3 subgroup (Figure 8D), while aminoacyl-tRNA biosynthesis, primary immunodeficiency, and RNA polymerase were significantly enriched in the low IRAK3 subgroup (Supplementary Figure 2D). Here, IRAK3 is linked to inborn error of immunity.