NFIL3 and nicotine dependence: B cell receptor signaling pathway, graft-vs.-host disease, legionellosis, leishmaniasis and osteoclast differentiation were significantly enriched in the high NFIL3 subgroup (Figure 8F), whereas drug metabolism - cytochrome P450, Linoleic acid metabolism, and nicotine addiction were significantly enriched in the low NFIL3 subgroup (Supplementary Figure 2F).