Over the past 25 years, 17 genes have been reported in association with LQTS; however, a recent literature curation by an international expert group found only 6 genes –KCNQ1, KCNH2, SCN5A, and CALM1-3 to have definitive evidence for causing LQTS (8). The gene discussed is KCNH2; the disease is familial long QT syndrome.