VWF and cardiovascular disorder: Moreover, when the VWF: Ag levels were divided into two groups according to a VWF: Ag cut-off value of 0.7884 IU/ml, a 6.004 fold increased risk of MACEs was noted (HR = 6.004 95%CI: 2.987–12.070) per SD, P < 0.01, Table 4) in the model fully adjusted for conventional risk factors for cardiovascular disease.