PPARG and pulmonary arterial hypertension: PPARγ activation through endogenous ligands or pharmacological compounds has been shown to convey a broad spectrum of beneficial functions in the pulmonary vasculature from facilitation of normal cell signaling to maintaining pulmonary vascular cell homeostasis and promoting reverse remodeling of pathological vascular changes associated with PAH (28, 32–34, 46, 53, 63, 66, 67, 69, 215–219).