TP53 and pulmonary arterial hypertension: In a genetic PAH model with endothelial cell-specific BMPR2 knockout Nutlin-3 induces formation of the PPARγ-p53 complex and upregulation of complex target genes in lung microvascular EC was associated with reversal of persistent pulmonary hypertension, PA remodeling, and regeneration of pulmonary microvessels (28).