In a genetic PAH model with endothelial cell-specific BMPR2 knockout Nutlin-3 induces formation of the PPARγ-p53 complex and upregulation of complex target genes in lung microvascular EC was associated with reversal of persistent pulmonary hypertension, PA remodeling, and regeneration of pulmonary microvessels (28). The gene discussed is PPARG; the disease is pulmonary arterial hypertension.