While FOXM1 is overexpressed in PASMC of PAH patients and promotes hypoxia-induced proliferation as well as resistance against apoptosis and DNA repair (90–92), FOXO1, which integrates multiple vasculoprotective pathways, shows reduced expression and/or is inactivated in PAH PASMC (93). The gene discussed is FOXO1; the disease is pulmonary arterial hypertension.