In general, at least 12 different pharmacological inhibitors of HIF1 and HIF2α were able to attenuate, prevent or reverse experimental pulmonary hypertension in rats or mice [reviewed in (157)] and multiple strategies appear feasible: Besides pharmacological inhibition of HIF signaling, destabilization of HIF via activation of HIF-degrading enzyme cascades or disruption of HIF complexes have all shown promising results as potential therapeutic strategies in experimental PH (and, partly, in ECs isolated from PAH patients) (208–210). Here, EPAS1 is linked to pulmonary hypertension.