SGCB and pulmonary arterial hypertension: Currently available pharmacological options in PAH comprise vasodilatory drugs with selectivity for the pulmonary vasculature that attenuate disease progression; namely endothelin receptor antagonists (ERA: bosentan, ambrisentan, and macitentan), phosphodiesterase 5 inhibitors (PDE5i: sildenafil, tadalafil), or soluble guanylate cyclase (sGC: riociguat) stimulator in addition to prostanoids/prostacyclin receptor agonist (epoprostenol, iloprost, treprostinil, selexipag) (9, 10).