To further complicate matters, EZH2 is able to regulate CD8+ T cells via activation of Id3 and inhibition of Id2 and Eomes (a TF which also plays an important role in T cell exhaustion and has been reviewed elsewhere (Li et al., 2018)) which together promote memory T cell formation and tumor control (He et al., 2017). This evidence concerns the gene EZH2 and neoplasm.