It has been reported that TEX isolated from supernatants of tumor cell lines carry on their surface immunosuppressive ligands, FasL, TRAIL and immunosuppressive proteins such as TGF-β or CD39/CD73, and suppress functions of immune cells in vitro and in vivo in tumor-bearing mice (Ludwig et al., 2018; Razzo et al., 2020). The gene discussed is TNFSF10; the disease is neoplasm.