The impact of exosomes produced from hBM-MSCs overexpressing miR-205 on the advancement of PCa was investigated, and the findings indicated that the transfer of miR-205 from hBMSCs to PCa cells by modified exosomes reduces multiplication, redistribution, and penetration of PCa cells through adhering to the 3′UTR of RHPN2 which led to its suppression. This evidence concerns the gene RHPN2 and posterior cortical atrophy.