ACLY and neoplasm: A non-toxic strain of Salmonella have been used to treat CT26 tumor-bearing mice in order to examine bacteria-mediated immune responses and the results showed that the ΔppGpp Salmonella strain has the ability to activate inflammasome and activate several citochines confirming an antitumoral activity (Kim et al., 2015) Tumor-targeting bacteria can also be engineered to express cytotoxic agents with intrinsic antitumor activity such as cytolysin A (Cly A).