CD274 and cancer: Because both PD-L1 expression (Patel and Kurzrock, 2015) and TMB (Goodman et al., 2017) are positive predictors of the response to immune checkpoint inhibitors (ICIs) and SFG mutations have heightened PD-L1 expression and TMB in cancer, we anticipated that SFG-mutated tumors would respond better to ICIs than SFG-wildtype tumors.