Recurrent somatic mutations of the SFG, such as SF3B1, SRSF2, U2AF1, and ZRSR2, have been uncovered in myelodysplastic syndrome (MDS) (Yoshida et al., 2011), chronic lymphocytic leukemia (Mansouri et al., 2013), acute myeloid leukemia (Cancer Genome Atlas Research et al., 2013), breast cancer (McCullough, 2013), lung adenocarcinoma (Imielinski et al., 2012), and uveal melanoma (Harbour et al., 2013). The gene discussed is ZRSR2; the disease is myelodysplastic syndrome.