They illustrated that adipose-derived stem cell-derived exosome (ADSC-Exo) vividly ameliorated DN symptoms by enhancing the expression of miR-486, which led to the inhibition of the Smad1/mTOR signaling pathway in podocyte. Possibly, ADSC-Exo can be used as a main therapeutic strategy for DN in the future. This evidence concerns the gene SMAD1 and liver dysplastic nodule.