They indicated that urinary exosomal miRNA content is altered in type II diabetic patients with diabetic nephropathy (DN). Deregulated miR-320c, which might have an impact on the TGF-β-signaling pathway via targeting thrombospondin 1 (TSP-1), shows promise as a novel candidate marker for disease progression in type II DN. This evidence concerns the gene TGFB1 and liver dysplastic nodule.