Wang et al. (2020) revealed that gambogenic acid (GNA) could suppress the invasive and migratory capacities as well as the EMT process in melanoma cells, which showed signature ferroptosis morphological changes. Through upregulating TP53 activity, GNA lowered the expression levels of GPX4 and SLC7A11, leading to dysregulation of cellular lipid peroxides, and eventually ferroptosis in transforming growth factor-β1 (TGF-β1)-induced EMT melanoma models (Wang et al., 2020). This evidence concerns the gene GPX4 and melanoma.