CHRNA7 and early-onset autosomal dominant Alzheimer disease: Based on these functions, α7nAChR is implicated in cognitive processes and synaptic plasticity (Shen and Yakel, 2009), neurotransmitter release and immune responsiveness with consequent implications for Alzheimer’s disease, Parkinson’s disease and so on (Schaaf, 2014; Quik et al., 2015; Liu et al., 2017).