Univariate analysis showed that neutrophil-to-lymphocyte ratio (NLR) and systemic inflammatory response index (SIRI) were associated with lymph node metastasis, while platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR), systemic immune inflammatory index (SII), prognostic nutritional index (PNI), fibrinogen to albumin or prealbumin ratio (FAR/FpAR) were not associated with lymph node metastasis, and multivariate analysis showed that only SIRI was a risk factor for lymph node metastasis. The gene discussed is ALB; the disease is metastatic malignant neoplasm in the lymph nodes.