Meanwhile, with the upregulation of pro-inflammatory cytokines and acute-phase proteins and activation of the hypothalamic-pituitary-adrenal axis, there is an increase or decrease in the levels of some hormones, including cortisol, catecholamines, insulin, and glucagon, which promote glycogen catabolism and gluconeogenesis in muscle tissue that induces hyperglycemia to compensate for the “concentration gradient” needed for tissue repair (20). This evidence concerns the gene INS and Hyperglycemia.