Through univariate analysis, other important factors that were potentially found to affect the prognosis of colon cancer patients, including laparoscopic surgery, ascites, swollen lymph nodes at the root of the mesentery, liver metastases, nerve invasion, vascular invasion, TNM staging, positive expression of tumor markers CA19-9, CA125, CA72-4, and positive combined detection of CEA, CA19-9, CA125, and CA72-4 (P < 0.05). The gene discussed is CEACAM5; the disease is malignant colon neoplasm.