Therefore, in the aspect of colon cancer, the combined detection of CEA, CA19-9, CA125 and CA72-4 can not only make up for the shortcomings of different sensitivity and specificity of a single tumor marker, but also facilitate the early diagnosis and treatment, which contributes to taking corresponding treatment measures more timely and prolonging the survival time of patients with colon cancer to a possible extent. The gene discussed is CEACAM5; the disease is colonic neoplasm.