Combined with the latest consensus of the International Society of Urological Pathology (ISUP) (34), Clear cell renal cell carcinoma (CCRCC) is the most common subtype of renal cell carcinoma, accounting for 65%–70% of renal tumors (35), Carbonic anhydrase IX (Carbonic anhydrase IX), CAIX) and CD10 membrane positivity is considered to be a relatively specific diagnostic indicators. The gene discussed is MME; the disease is renal cell carcinoma.