The phosphatidylinositol 3-kinase (PI3K)/AKT serine/threonine kinase 1 (AKT)/mammalian target of rapamycin (mTOR) signaling pathway is overactivated or altered in many cancer types, thereby regulating a wide range of cellular processes, such as the cellular survival, proliferation, growth, metabolism, angiogenesis, and metastasis. This evidence concerns the gene MTOR and cancer.