CD8A and neoplasm: We speculate that the reason for this phenomenon in the low-NLR environment is that the ratio of neutrophils to lymphocytes was lower under low NLR conditions, indicating that the anti-tumor effect (mediated by antitumor-associated lymphocytes, including CD8 + T (32, 33) and natural killer T cells (34–36)) in the tumor microenvironment is to a certain extent better than the tumor-promoting effect [mediated by the monocyte-macrophage system (37, 38)].