In a series of studies, Kamerkar et al.22, 107, 108have shown that sEV loaded with ASO (ExoASO) targeting STAT6 or C/EBPβ, key transcription factors that control the immunosuppressive program of TAMs, induces macrophage reprogramming to a pro‐inflammatory M1‐like phenotype which results in a potent‐single agent anti‐tumor activity in multiple checkpoints refractory tumor models. The gene discussed is STAT6; the disease is neoplasm.