CD274 and cancer: Activated by TME‐derived factors, these PD‐L1+ TAMs mediate CD8+ T‐cell dysfunction through the PD‐1/PD‐L1 axis, observations reported in several types of cancer as hepatocellular carcinoma,56 ovarian cancer,57 bladder cancer,58 soft tissue sarcoma,59 head, and neck squamous cell carcinoma,60 and cholangiocarcinoma.61