Activated by TME‐derived factors, these PD‐L1+ TAMs mediate CD8+ T‐cell dysfunction through the PD‐1/PD‐L1 axis, observations reported in several types of cancer as hepatocellular carcinoma,56 ovarian cancer,57 bladder cancer,58 soft tissue sarcoma,59 head, and neck squamous cell carcinoma,60 and cholangiocarcinoma.61 This evidence concerns the gene CD274 and hepatocellular carcinoma.