CLDN2 and colitis: In the absence of permeability increases (Figure 3), damage to the mucosa seen in imaging (Figure 6), persistent diarrhea or other fecal abnormalities (Figure 4c), weight loss (Figure 4a), or increased inflammatory markers in the serum (Figure 4b), we are not concerned that this observed upregulation of claudin 2 indicates the onset of a colitis‐like state.