The enhanced antitumor immune response caused by the combination of FPC2‐IG‐IL‐2 and anti‐PD‐1 antibody was further demonstrated in tumor‐infiltrating CD8+T cells that exhibited a higher frequency of IFN‐γ expression upon stimulation with AH1 peptide, the immunodominant antigen of CT26 (Figure 4g). This evidence concerns the gene DDX53 and neoplasm.