To determine the clinical value of targeting CHK1 and BRD4 in MYC‐driven HCC, we assessed the role of CHEK1 and BRD4 expression in the pathogenesis of HCC in patients from the Genomic Data Commons (GDC) The Cancer Genome Atlas Liver Hepatocellular Carcinoma (TCGA‐LIHC) data set. The gene discussed is BRD4; the disease is hepatocellular carcinoma.