However, MYC expression contributes to the development and progression of aggressive HCC as there was a greater distribution of patients with higher grade tumors (neoplasm histologic grade 3 or 4) in the MYCHi group versus the MYCLo group (42.62% vs. 31.18%) (Figure 4cii,iii). This evidence concerns the gene MYC and hepatocellular carcinoma.