Based on the iterations of QPOP analyses performed on HCC cell lines stratified based on their levels of MYC expression, CHK1 and BRD4 have been identified as the most promising target combination against MYC‐driven HCC as simultaneous functional knockout of both targets were among the top‐ranking combinations in only MYCHi cell lines. This evidence concerns the gene MYC and hepatocellular carcinoma.