First, ssCHK1 and ssBRD4 hindered G1/S transition cell cycle progression by depleting MYC and cyclin D1 levels, while simultaneously upregulating tumor suppressor genes in HCC, preventing cell growth in target cells.52, 73, 74, 75, 76, 77, 78. The gene discussed is CCND1; the disease is hepatocellular carcinoma.