Besides, these nanocarriers mediated endosomal escape of ElF5A2‐siRNA to release it in cytoplasm for downregulation of ElF5A2 as a tumor‐promoting factor to suppress proliferation and invasion of bladder tumor cells and to stimulate apoptosis via Bax upregulation and Bcl‐2 downregulation.165. The gene discussed is BCL2; the disease is neoplasm.