Sebastiani and co-authors (8) showed that 130 genes associated with the human lifespan were enriched for several groups of genes linked to both AD and Coronary Artery Disease (CAD) including TOMM40/APOE and CDKN2A. On the contrary, in study by Beekman et al. (9) the authors compared the cumulative effect of risk alleles for cardiovascular disease, type 2 diabetes, and cancer between individuals aged 85 years and older and the middle-aged general population and found that longevity is not compromised by this cumulative effect. Here, APOE is linked to Alzheimer disease.