Interestingly, the G allele of rs10774624 (locus 17, RP3-473L9.4), rs1964272 (locus 22, SNRPD2), rs10818576 (locus 13, DAB2IP), and rs9630903 (locus 20, FCHO1) has the same direction of association for AD and longevity and opposite for CAD despite the negative genetic correlation between AD and longevity (Supplementary Tables S3, S4). The gene discussed is DAB2IP; the disease is Alzheimer disease.