APOE and Alzheimer disease: More specifically, the two SNPs located in chromosome 19 (82 Kb and 34 Mb away from the APOE gene, respectively) were positively associated with longevity and negatively associated with AD and CAD: rs117261169-T ORcluster = 1.39, Pcluster = 1.20e-04 vs. ORcluster = 0.78, Pcluster = 8.85e-09, and rs2043332-A ORcluster = 1.05, Pcluster = 2.39e-02 vs. ORcluster = 0.95, Pcluster = 2.48e-08, respectively.