CARF and cerebral small vessel disease: SNP rs116426890 is intronic to ABI2 and is linked to the expression of CARF, ICA1L, FAM117B, and NBEAL1 (Supplementary Table S7) which are associated with both white matter hyperintensities and fractional anisotropy, predictors of cerebral small vessel disease which is involved in strokes and vascular dementia (80).