FCHO1 is involved in endocytosis via clathrin coated endocytic vesicle pathways (49) binds APP and its missense mutation NM_001161357.1:c.557G > A (rs147599881) approached significance in the cerebrospinal fluid (CSF) biomarker data in a recent analysis of AD-affected cousin pairs selected from high-risk pedigrees (50). This evidence concerns the gene FCHO1 and Alzheimer disease.