Two of the five pleiotropic loci identified by Fortney et al. (48) using data from centenarian cohorts for age-related traits, TOMM40/APOE (shared by longevity and AD) and CDKN2B-AS1 (shared by longevity and CAD), were also returned by our subset-based meta-analysis (the SNPs mapped in these genes in both studies were in LD). This evidence concerns the gene APOE and Alzheimer disease.