ANF/ANP exhibits diuretic, natriuretic, vasorelaxant, neurotransmission, antimitogenic, and anti-inflammatory responses directed largely toward the reduction of blood pressure (BP) and protection against renal and cardiovascular disorders (Brenner et al., 1990; Levin et al., 1998; Pandey, 2005; Ellmers et al., 2007; Pandey, 2008). This evidence concerns the gene NPPA and cardiovascular disorder.