CD8A and neoplasm: It can promote cross-presentation by stimulating the maturation of DCs, slowing down the endosome–lysosome acidification process to prevent phagocytic tumor antigen clearance, and increasing the expression of cell surface MHC I molecules, which accelerates DC migration to lymph nodes to cross-trigger tumor-specific CD8+ T cells (Reboulet et al., 2010; Diamond et al., 2011; Lorenzi et al., 2011; Zheng et al., 2020).