DARS1 and Alzheimer disease: Also, we observed an enrichment in overlap between the genes annotated to these DARs and the genes that were differentially expressed (FDR q < 0.05) in oligodendrocytes of subjects with AD in the snRNA-seq dataset (no pathology vs. early pathology hypergeometric p = 2.8e-4, no pathology vs. pathology p = 2.1e-4).