APOE and Alzheimer disease: Secondly, at the locus containing the BIN1 gene, which displays the second largest genome wide AD association behind the APOE locus, two sentinel SNPs, rs4663105 (GWAS p-values = 3.37e-44, 2.16e-26) and rs6733839 (GWAS p-values = 1.28e-29, 4.02e-28), overlap with a peak significantly enriched in both microglia and OEG, but not neurons (log2fc Neuron = −0.74; log2fc Microglia = 0.21, q = 2.66e-3; log2fc OEG = 0.53, q = 2.11e-15) (Figure 2E).