SLITRK1 and Tourette syndrome: Administration of clonidine, an a2-adrenergic agonist that is frequently used to treat patients with Tourette’s syndrome and OCRD, attenuated the anxiety-like behavior of Slitrk1 KO mice (Figure 2A; Katayama et al., 2010), suggesting NA dysregulation to be associated with anxiety-like behaviors.