The studies initiated by the De Bold’s group and followed by others’ revolutionized the field of cardiovasculature and provided an opening for advancing the ANF research toward the development of drugs for hypertension (De Bold, 1982; Cantin and Genest, 1985; Schwartz et al., 1985; Atlas and Laragh, 1986; De Bold, 1986). Here, NPPA is linked to hypertensive disorder.