Multiple regression analysis showed that the expressions of anti-SSB and positive RF were independent protective factors for thrombocytopenia in C-pSS patients (OR = 0.028, 95%CI 0.002–0.427, P = 0.010; OR = 0.020, 95%CI 0.001–0.291, P = 0.004, respectively) (Supplementary Table S2). This evidence concerns the gene SSB and Thrombocytopenia.