Moreover, dry eyes were more likely to occur in patients with a negative anti-SSA/Ro52 (P = 0.020), and hyperglobulin was more likely to occur in patients with positive RF and anti-SSA/Ro60 (P = 0.031 and P = 0.049, respectively) (Figure 1). The gene discussed is TRIM21; the disease is Keratoconjunctivitis sicca.