Whereas genetic predisposition to developing severe MIS-C has been demonstrated (19), the true triggers for the severe inflammatory response seen in otherwise healthy individuals with MIS-C and characterized by increased plasma cytokine levels including IL-6, IL-8, IFNγ, IL-17, TNFα, and IL-10 and the multilineage immune cell activation remain unknown (20–24). The gene discussed is TNF; the disease is COVID-19–associated multisystem inflammatory syndrome in children.