Inflammatory macrophages can promote the progression of atherosclerosis by expressing surface markers, including primary histocompatibility complex class II, Fc receptor CD64 and costimulatory molecules CD80 and CD86, and secrete chemokines and cytokines to promote vascular inflammation, including monocyte chemoattractant protein-1 (MCP-1), interleukin-1 (IL-1), IL-6, IL-12, IL-15, IL-18, IL-23 and tumor necrosis factor α (TNF-α) [4, 25]. The gene discussed is TNF; the disease is atherosclerosis.