Considering that, the LMP1-mediated activation of ERK/MAPK, PI3K/AKT, NF-κB, and JAK/STAT signaling pathways, promoting NPC cell proliferation and survival (Tsao et al., 2002; Li and Chang, 2003; Morris et al., 2009), and we then focused on the study of molecular mechanisms of ZLMP1-C treatment that induce an inhibitory effect on NPC cells proliferation. This evidence concerns the gene AKT1 and nasopharyngeal carcinoma.