All of these domains are essential for protein-protein interaction that regulate a variety of signal transduction pathways, which include ERK-MAPK, JAK/STAT, PI3-K/Akt and NF-κB JNK/p38-SAPK, to promote NPC tumor growth and invasion (Tsao et al., 2002; Li and Chang, 2003; Morris et al., 2009). The gene discussed is NFKB1; the disease is nasopharyngeal carcinoma.