AKT1 and injury: In addition, GRg3 has been reported to be involved in the regulation of the activation of the phosphoinositide 3-kinase (PI3K)/protein kinase B (PKB, also known as AKT)/mammalian target of rapamycin (mTOR) and inhibition of the NF-κB signaling pathways and has, therefore, been widely used in the treatment of acute lung injury (Cheng and Li, 2016; Lee et al., 2016; Yang et al., 2018).