Flavonoid dihydromyricetin (DHM) supplementation mitigates nonalcoholic fatty liver disease by improving mitochondrial respiratory capacity and oxidative balance in hepatocytes via a SIRT3‐dependent mechanism.[61] Meanwhile, DHM‐SIRT3 activation prevents chondrocytes from inflammatory cytokines‐induced ECM degradation and maintains mitochondrial metabolic equilibrium.[62] Melatonin, N‐acetyl‐5‐methoxytryptamine, is a highly conserved indoleamine secreted from the pineal gland. Here, SIRT3 is linked to metabolic dysfunction-associated steatotic liver disease.