More specifically, the delivery of Au@GO NP‐BCL2‐NACs combined with Cy5 Raman dye (Au@GO NP‐Cy5‐BCL2‐NACs) into cancer cells induced a selective binding between ASON and overexpressed BCL2 mRNA, causing the disruption of π‐π stacking and the subsequent release of Cy5 molecules through a double‐strand formation, thus reducing the SERS signal (Figure 17J). This evidence concerns the gene BCL2 and cancer.