Circular RNAs (circRNAs) are characterized by their structural covalent closed‐loop structure, and widespread among eukaryotes.[18, 19, 20] They have been demonstrated to post transcriptionally mediate the immune response‐ and tumorigenesis‐related gene expression.[21, 22, 23] Recent studies reveal that circRNAs are important in NF‐κB signaling regulation.[24, 25] However, much remains be elucidated about circRNAs involvement in SASP‐related NF‐κB activation in NPC. The gene discussed is NFKB1; the disease is nasopharyngeal carcinoma.