NF‐κB is a transcription factor complex essential for the cellular response to inflammatory stimuli and stress signals.[32] Consistent with its critical roles in inflammation, NF‐κB directly regulates the transcription of key proinflammatory SASP subset genes.[13, 14] Constitutive activation of NF‐κB signaling, which can promote cancer immune evasion and systemic dissemination, has been frequently observed in NPC.[57] However, the endogenous molecule sustaining NF‐κB activation is largely unclear yet. The gene discussed is NFKB1; the disease is nasopharyngeal carcinoma.