CCND1, a p16 inhibitor, activates the cyclin‐dependent kinase 4/6 (CDK4/6), which induces cell cycle progression through the G1/S phase checkpoint to overcome cell cycle arrest,[7] possibly explaining the mechanism through which circWDR37 deficiency sensitized NPC cells to cisplatin‐ or gemcitabine‐induced senescence through downregulating Cyclin D1 expression. Here, CDK4 is linked to nasopharyngeal carcinoma.