The secretion of proinflammatory cytokines, chemokines, and growth factors is the main characteristic of SASP.[12] Nuclear factor kappa B (NF‐κB) is a key molecular module involved in SASP generation.[13, 14] Accumulating genomic studies have reported that somatic alterations and epstein‐barr virus (EBV) cooperate to sustain inflammatory NF‐κB activation in NPC.[15, 16, 17] Nonetheless, the somatic variation rate is relatively low for individual NPC patients, and the endogenous molecules sustaining constitutive NF‐κB activation are not clear yet. This evidence concerns the gene NFKB1 and nasopharyngeal carcinoma.