Ldlr−/− mice with Dpp4−/− bone marrow had smaller atherosclerotic plaques than those with Dpp4+/+ bone marrow under HFD (50.69 ± 4.62% versus 30.12 ± 5.85% for HFD bmDpp4+/+ versus HFD bmDpp4−/−, p < 0.001; Figure 4b,c), suggesting that hematopoietic deficiency of DPP4 reduced HFD‐induced atherosclerosis progression. This evidence concerns the gene LDLR and atherosclerosis.