E2F1 and hyperinsulinemic hypoglycemia, familial, 4: In mice, the fact that the Enrichment TF analysis did not allow to emerge E2F1 could be linked to several features associated with the model and the analysis: (i) Enrichment TF analysis is based on the more altered genes; (ii) astrocyte and rat models are obtained by inducing nutritional VitB12 deficiency; and (iii) in mice, THAP11 mutation can have a lower and indirect role in “Ribosome” pathway and a prominent direct role on several other different pathways.